Our Services
Why Aracari?
When it comes to treating patients, most therapeutics are delivered through the blood vessels, including small molecules, antibodies, and immune cells. This is also true in Aracari’s platforms, where self-assembled human blood vessels not only support tissue growth through delivery of nutrients, but also deliver drugs and cell therapies. Aracari’s vascularized microphysiological systems therefore provide more relevant, physiological data for accelerating drug development.
Core Service Features
Access to cutting-edge, vascularized microphysiological testing platforms
Personalized expert consultation to reach your project goals using Aracari’s technology
Confidential communication of project objectives & results
Customized downstream read-outs
Let Us Custom Design Your Next Study
Oncology Studies
Aracari’s Vascularized Micro-Tumor (VMT™) platform allows for testing the efficacy of lead compounds in inhibiting tumors growing in a vascularized, biomimetic environment. Our oncology services include:
- Delivery of therapeutics to tumors via blood vessels
- Measurement of tumor growth inhibition
- Tumor occupancy (e.g. T cells, oncolytic virus, etc.)
- And more
Immuno-Oncology (IO) Studies
Aracari’s Vascularized Micro-Tumor (VMT™) platform allows for physiological investigation of IO therapeutics. Our IO services include:
- Leukocyte vessel adhesion & extravasation
- Parallel delivery of leukocytes & IO therapies, such as
monoclonal antibodies & bispecifics - Tumor occupancy by T cells, including CAR-Ts
- Cytokine expression, and more
Blood-Brain Barrier Studies
Aracari’s Vascularized Micro-Brain (VMB™) platform is ideally suited for investigating drug delivery across the blood-brain barrier. Our blood-brain barrier (BBB) services include:
- Physiological delivery of drugs across the BBB.
- Tissue toxicities in brain stromal compartment
- Tissue extraction for qRT-PCR and bulk or single cell RNA seq.
- And more
Vascular Toxicity & Permeability Studies
Our vascularized platforms are ideal for testing therapies for unexpected toxicity before delivery to patients. Our toxicity services include:
- Drug-induced vessel leak (permeability)
- Morphological damage to vessel network
- Apoptotic marker expression (tissue staining)
- And more
How Aracari is Different
Other MPS
Companies
3D tissues fed by living, human blood vessel network
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Drug delivery via perfusable blood vessels
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Vascular networks supportive of leukocyte extravasation
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Multi-MPS format supportive of parallel drug screening
Non-drug absorbing plastic framework
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Research collaboration service
How Aracari is Different
