Publications

Aracari’s platforms have been extensively validated & published in multiple peer-reviewed journals. These publications are categorized in the following subject areas.

Featured Publications

Organ-on-a-chip model of vascularized human bone marrow niches

Human in vitro vascularized micro-organ and micro-tumor models are reproducible organ-on-a-chip platforms for studies of anticancer drugs

An in vitro vascularized micro-tumor model of human colorectal cancer recapitulates in vivo responses to standard-of-care therapy

Oncology

Organ-on-a-chip model of vascularized human bone marrow niches

Tumor-on-chip modeling of organ-specific cancer and metastasis

Engineering Vascularized Organoid-on-a-Chip Models

An in vitro vascularized micro-tumor model of human colorectal cancer recapitulates in vivo responses to standard-of-care therapy

Human in vitro vascularized micro-organ and micro-tumor models are reproducible organ-on-a-chip platforms for studies of anticancer drugs

Tumor-on-a-chip platform to interrogate the role of macrophages in tumor progression

Tumor-on-a-chip platform to investigate progression and drug sensitivity in cell lines and patient-derived organoids

Applications of tumor chip technology

3D microtumors in vitro supported by perfused vascular networks

A strategy for integrating essential three-dimensional microphysiological systems of human organs for realistic anticancer drug screening

Immuno-Oncology

Tumor-on-a-chip platform to interrogate the role of macrophages in tumor progression

Small Molecule Oncology

Human in vitro vascularized micro-organ and micro-tumor models are reproducible organ-on-a-chip platforms for studies of anticancer drugs

Tumor-on-chip modeling of organ-specific cancer and metastasis

An in vitro vascularized micro-tumor model of human colorectal cancer recapitulates in vivo responses to standard-of-care therapy

Tumor-on-a-chip platform to investigate progression and drug sensitivity in cell lines and patient-derived organoids

Applications of tumor chip technology

3D microtumors in vitro supported by perfused vascular networks

A strategy for integrating essential three-dimensional microphysiological systems of human organs for realistic anticancer drug screening

Toxicity

Organ-on-a-chip model of vascularized human bone marrow niches

Tumor-on-a-chip platform to investigate progression and drug sensitivity in cell lines and patient-derived organoids

A strategy for integrating essential three-dimensional microphysiological systems of human organs for realistic anticancer drug screening

A vascularized and perfused organ-on-a-chip platform for large-scale drug screening applications

3D microtumors in vitro supported by perfused vascular networks

Vasculature

The vascular niche in next generation microphysiological systems

Engineering Vascularized Organoid-on-a-Chip Models

Human in vitro vascularized micro-organ and micro-tumor models are reproducible organ-on-a-chip platforms for studies of anticancer drugs

A modular microfluidic system based on a multilayered configuration to generate large-scale perfusable microvascular networks

Applications of tumor chip technology

Engineering perfused microvascular networks into microphysiological systems platforms

A vascularized and perfused organ-on-a-chip platform for large-scale drug screening applications

3D microtumors in vitro supported by perfused vascular networks

Engineering anastomosis between living capillary networks and endothelial cell-lined microfluidic channels

A strategy for integrating essential three-dimensional microphysiological systems of human organs for realistic anticancer drug screening

In vitro perfused human capillary networks

A microfluidic platform for generating large-scale nearly identical human microphysiological vascularized tissue arrays

Full range physiological mass transport control in 3D tissue cultures

Aracari Platform Features

A modular microfluidic system based on a multilayered configuration to generate large-scale perfusable microvascular networks

Tumor-on-a-chip platform to interrogate the role of macrophages in tumor progression

A vascularized and perfused organ-on-a-chip platform for large-scale drug screening applications

3D microtumors in vitro supported by perfused vascular networks

An on-chip microfluidic pressure regulator that facilitates reproducible loading of cells and hydrogels into microphysiological system platforms

Engineering anastomosis between living capillary networks and endothelial cell-lined microfluidic channels

In vitro perfused human capillary networks

A microfluidic platform for generating large-scale nearly identical human microphysiological vascularized tissue arrays

Full range physiological mass transport control in 3D tissue cultures

Independent Validation

Human in vitro vascularized micro-organ and micro-tumor models are reproducible organ-on-a-chip platforms for studies of anticancer drugs

Microphysiological Systems Overview

The vascular niche in next generation microphysiological systems

Engineering Vascularized Organoid-on-a-Chip Models

Tumor-on-chip modeling of organ-specific cancer and metastasis

Applications of tumor chip technology

Engineering perfused microvascular networks into microphysiological systems platforms

Blood-brain barrier-on-a-chip: Microphysiological systems that capture the complexity of the blood-central nervous system interface

A strategy for integrating essential three-dimensional microphysiological systems of human organs for realistic anticancer drug screening

Blood-Brain Barrier

Blood-brain barrier-on-a-chip: Microphysiological systems that capture the complexity of the blood-central nervous system interface

Bone Marrow

Organ-on-a-chip model of vascularized human bone marrow niches

A strategy for integrating essential three-dimensional microphysiological systems of human organs for realistic anticancer drug screening

Personalized Medicine

Tumor-on-a-chip platform to investigate progression and drug sensitivity in cell lines and patient-derived organoids

Applications of tumor chip technology