Our Technology
Vascularized Microtissues Are Our Specialty
Most cells in our body are no farther from a blood vessel than the width of a hair. Blood vessels help pattern tissues and provide them with their nutrients, and since almost all therapeutics — whether small molecules, antibodies, or leukocytes — reach our tissues via blood vessels, no model of tissue-drug interaction is realistic without this supporting vascular network. Our vascularized organ and tumor chips provide more relevant, physiological results for accelerating drug development.
![Image of Abraham P. Lee, Ph.D.](https://aracaribio.com/wp-content/uploads/2022/05/Lee-greyscale-e1651511424225.jpeg)
Why Use Vascularized Tissues?
Mimic blood flow & permeability of vessels in the body
Ideal for both efficacy & toxicity testing
Deliver nutrients & remove tissue waste
Deliver therapeutics directly to 3D tissues
Recapitulate cross-talk between vessels, stroma, and tissue-specific cells
Transport immune cells, such as leukocytes or CAR-T cells
Explore Our Vascularized Tissue Platforms
Vascularized Micro-Organ (VMO™)
![Image of Perfused Vessels](https://aracaribio.com/wp-content/uploads/2021/11/Vessels_Perfused.jpg)
Aracari’s VMO™ platform is ideal for understanding the physiological responses of vessels to pro- and anti-angiogenic therapies. The composition of the VMO™ also simplifies studies aimed at testing therapy toxicity, both to blood vessels & the surrounding tissues. Key features of the VMO™ include:
- Human endothelial cells
- Human stromal cells (pericytes)
- 3D matrix replicating native vessel matrices
- And more
Vascularized Micro-Tumor (VMT™)
![Image of vessels and tumor](https://aracaribio.com/wp-content/uploads/2021/11/VMT.jpg)
Aracari’s VMT™ platform is ideal for testing lead compound efficacy in inhibiting tumors growing in a biomimetic environment. Comprised of endothelial & stromal (pericyte) cells, our VMT™ also includes the following human tumors:
- Colon Cancer (at left)
- Lung Cancer
- Customized Tumors of Interest
- And more
Vascularized Micro-Brain (VMB™)
![Image of Blood Brain Barrier](https://aracaribio.com/wp-content/uploads/2021/11/VMB.jpg)
Aracari’s VMB™ platform is designed to test therapeutic permeability across the blood-brain barrier (BBB). Our VMB™ includes:
- Human endothelial cells
- Human stromal (pericyte) & glial (astrocyte) cells
- Enrichment of BBB genes, including Claudin5, Occludin, Glut-1, P-glycoprotein, & MRP4
- And more
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